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Dept of Microbiology and Immunology Seminar - Dr. Craig MacLean

February 22, 2018 - 2:00pm

Life Sciences Centre

2350 Health Sciences Mall



The Evolutionary Biology of Antibiotic Resistance
Dr. Craig MacLean
Wellcome Trust Senior Research Fellow, Department of Zoology, University of Oxford

Antibiotic resistance in pathogenic bacteria has emerged as a fundamental threat to human health.Research in my lab is focused on understanding the fundamental evolutionary processes that drive the spread and maintenance of resistance using an integrative approach that combines experimental evolution, mathematical modeling and genomics. My talk will focus on addressing three main questions that have important implications for predicting and preventing the spread of resistance: (1) How does antibiotic resistance persist over the long term? (2) What are the genetic drivers of resistance evolution? (3) How does horizontal gene transfer drive evolutionary innovation? I will conclude by outlining key challenges for this field and by showing how it should be possible to bridge the gap between conceptual and clinical studies of resistance.

Handout-Dr. Craig MacLean Feb 22.pdf255.5 KB