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Dept of Biochemistry and Molecular Biology and Centre for Brain Health

March 8, 2018 - 1:00pm

David Mowafaghian Centre for Brain Health (CBH)

2215 Wesbrook Mall

CBH Conference Room 3402 A/B/C


Epigenomic Signatures of Microglia iin Autism
Annie Vogel Ciernia, PhD
Dept of Medical Microbiology and Immunology, University of California, Davis, USA
Djavad Mowafaghian Centre for Brain Health

Hosted by Dr. LeAnn Howe

Dr. Vogel Ciernia is a candidate for a Faculty Position in the Dept of Biochemistry and Molecular Biology, and Centre for Brain Health (BMB & CBH), UBC


My overall research interest is in understanding epigenetic mechanisms of transcriptional regulation involved in brain plasticity and neurodevelopmental disorders. My current focus is on understanding how alterations in DNA methylation contribute to changes in microglial transcriptional programming early in life. Using mouse models and human brain samples, my work indicates that epigenomic perturbations in neurodevelopmental disorders alter how microglia-neuron interactions shape the developing brain. Epigenomic insights into cell types and gene pathways in the developing nervous and immune systems will aid in defining therapeutic targets and early biomarkers at the interface of genetic and environmental risk factors for neurodevelopmental disorders. 

Seminar Annie Cierniai-Mar 8th 2018.pdf95.61 KB