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MSL Seminar Series: November – Invited Speaker, Dr. Peng Yin
November 19 @ 3:00 pm - 4:00 pm
Invited Speaker:
Dr. Peng Yin
Professor of Systems Biology, Harvard Medical School
Core Faculty Member, Wyss Institute for Biologically Inspired Engineering at Harvard University
Host: Dr. Sabrina Leslie
This seminar will be presented in a hybrid format. Audience members are welcome to attend either in person at the MSL lecture theatre (room 102) or via the zoom link. Those connecting via zoom will be able to ask questions during the Q&A portion using the chat function.
Zoom registration link: https://ubc.zoom.us/meeting/register/05K_lmMgQs-VBqby-gc-7g
Talk title: DNA-based molecular measurement tools
Abstract: Biological organisms are fundamentally organized molecular systems. To study such systems, we use synthetic DNA polymers to develop precise molecular measurement tools. I will describe examples that advance the performance and accessibility of spatial, single-cell, and single-molecule analyses, including (1) nano-imaging with molecular resolution and precise quantification, (2) scalable, high-plex protein and RNA imaging across micrometer- to millimeter-thick biospecimens with in situ signal amplification, (3) spatially prescribed full transcriptome sequencing in intact tissues, and (4) separation-free protein detection in biofluids with single-molecule level sensitivity via engineered kinetic proofreading.
