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MSL Seminar Series: June – Invited Speaker, Dr. Carrie Partch
June 21, 2023 @ 3:00 pm - 4:00 pm
Invited Speaker: Dr. Carrie Partch
Professor, Department of Chemistry and Biochemistry – University of California Santa Cruz
This seminar will be presented in a virtual format on Zoom. Please use the zoom registration link below to sign up to attend.
Zoom registration link:
https://ubc.zoom.us/meeting/register/u5MudemhpjoiGtcLt1Ge7hb1JnuBov5u7ATS
Talk title
An intrinsically disordered phosphoswitch controls circadian timekeeping in humans
Abstract
Our lives are intimately linked to Earth’s 24-hour solar cycle via circadian clocks that coordinate physiology and behavior into rhythms that coincide with the day/night cycle. We are integrating structural biology, biochemistry, and cell biology to identify how dedicated clock proteins interact with one another to establish a deeper understanding of the transcription-based feedback loop that underlies human circadian rhythms. Here, I will discuss how an intrinsically disordered phosphoswitch controls the activity of Casein kinase 1δ to determine the intrinsic timing of circadian clocks in humans.
Hosted by: Dr. Jörg Gsponer