Current Positions

NON-UNION RESEARCH ASSISTANT/TECHNICIAN 3 – JEFFERIES LAB

 Posting End Date: May 30, 2022

Application website
Applications will be reviewed as they are received and posting will remain open until filled.https://ubc.wd10.myworkdayjobs.com/ubcstaffjobs/job/UBC-Vancouver-Campus/Research-Assistant-Technician-3_JR7829

JOB SUMMARY
This Research Technician position in the Jefferies Lab is a great opportunity to contribute to Major Depressive Disorder research on a project to validate drug candidates for clinical development. This position will perform immunology experiments examining the role of genes and proteins in immune responses; extracting plasmid DNA; purify and digest with restriction enzymes; confirm correct sequence on nucleic acid gels; transfect mammalian cells with florescent antibodies; perform examinations using FACS analysis; analyze immuno-precipitates by SDS-Page gels. Due to the work involving the use of hazardous, biohazardous, and potentially controlled substances, the use of personal protective equipment, annual TB testing, and adherence to strict safety protocols is expected.

ORGANIZATIONAL STATUS
Reports directly to the Principle Investigator, Dr. Wilfred Jefferies. Works with Research Associates, Postdoctoral Fellows, and Research Technicians involved in the assigned project.

WORK PERFORMED

• Plans and performs experiments, utilizing polymerase chain reaction (PCR), qPCR, and other basic molecular biology techniques. Troubleshoots problems; collects, records, analyses and interprets experiment
• Performs molecular biology and immunology research to examine role of genes and proteins in immune responses
• Purifies and digests with restriction enzymes, and confirms correct sequence on nucleic acid gels
• Tests mammalian cells with florescent antibodies and performing examinations using FACS analysis
• Analyzes immunoprecipitates by SDS-Page gels
• Sets up sequential experiments, culturing and maintaining laboratory mammalian cell lines using tissue culture technology
• Isolates and cultures primary cells from
• Maintains a clean and orderly working environment in the
• Carries out lab tasks including pipetting, cleaning glassware, cleaning surfaces, taking inventories of consumables and
• Sets up, tests, operates and maintains common laboratory and other
• Organizes and maintains detailed documentation of work and reports results to the supervisor and members of the
• Carries out any other related duties as required in keeping with the qualifications and requirements of positions in this

QUALIFICATIONS
Undergraduate degree in a relevant discipline or graduation from a technical college or institute. Minimum of 3 years related experience or the equivalent combination of education and experience. BSc in molecular biology or related discipline preferred. Background in virology with experience and/or working knowledge of basic molecular biology techniques, tissue culture and flow cytometry, ELISAs, and other immunoassays. Biological and/or chemical safety certifications will be required.

SKILLS

• Physically able to operate equipment (standing, sitting)
• Effective communication skills and ability to work with well others
• Self-motivated and take initiative to perform work when supervisors are not present
• Willingness to learn basic computer skills
• Ability to communicate effectively
• Ability to work within a multicultural environment
• Demonstrated interest in science and excellent record keeping skills

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadian citizens and permanent residents will be given priority.

NON-UNION RESEARCH ANIMAL ASSISTANT/TECHNICIAN 3 – JEFFERIES LAB

Posting End Date: May 30, 2022

Additional information
Applications will be reviewed as they are received and posting will remain open until filled. https://ubc.wd10.myworkdayjobs.com/ubcstaffjobs/job/UBC-Vancouver-Campus/Research-Animal-Tech-3_JR7830

JOB SUMMARY
This Research Technician position in the Jefferies Lab is a great opportunity to contribute to Major Depressive Disorder research on a project to validate drug candidates for clinical development. This position requires thorough knowledge and experience working with cell cultures and mouse models. Due to the work involving the use of potentially controlled substances, the use of personal protective equipment, annual TB testing, and adherence to strict safety protocols is expected.

ORGANIZATIONAL STATUS
Reports directly to the Principal Investigator, Dr. Wilfred Jefferies. Works with Research Associates, Postdoctoral Fellows, and Research Technicians involved in the assigned project.

WORK PERFORMED

• Assist in the amendment, design, development and amendment of protocols for animal research.
• Coordinate, monitor and ensure the implementation of procedures following federal and University guidelines and policies on animal welfare.
• Monitor health, behavior and welfare of laboratory animals, along with continuous awareness of current species-specific welfare issues, such as common signs of illness, pain, trauma or depression, in accordance with CCAC guidelines
• Plan and perform animal research studies, including handling rodents, drug administration via sc, iv, ip and gavaging, disease model development in rodents, drug dose range finding, drug efficacy studies, and colony management.
• Perform necropsies, blood sampling and surgical procedures for animal work.
• Order animals for upcoming studies and purchase supplies and drugs needed for experiments.
• Train new research staff/trainees in animal work and ensure they are following animal welfare guidelines. 
• Organize and maintain detailed documentation of work and reporting results to the supervisor and members of the lab in a timely manner.
• Carry out any other related duties as required in keeping with the qualifications and requirements of positions in this classification. 

QUALIFICATIONS
Undergraduate degree in a relevant discipline or graduation from a technical college or institute. Minimum of 3 years related experience or the equivalent combination of education and experience. BSc in molecular biology or related discipline preferred, one year experience with stereotaxic surgical techniques, experience working with and handling animals, rodent behavioural changes and behaviour testing within parameters of ethics protocols at all times. Certifications in animal handling, anesthesia and/surgical techniques preferred, and chemical safety certifications.

SKILLS

• Experience and/or working knowledge of husbandry and genotyping
• Physically able to operate equipment (standing, sitting)
• Effective communication skills and ability to work with well others
• Self-motivated and take initiative to perform work when supervisors are not present
• Willingness to learn basic computer skills
• Ability to communicate effectively
• Ability to work within a multicultural environment
• Demonstrate an interest in science and excellent record keeping skills

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadian citizens and permanent residents will be given priority.

Postdoctoral Research Fellow in Drug Eluting Devices

The Kizhakkedathu and Withers laboratories at the University of British Columbia (UBC) in Vancouver, BC, Canada invite applications for multiple postdoctoral research fellow positions (Kizhakkedathu Lab (https://cbr.ubc.ca/our-people/investigators/jayachandran-kizhakkedathu/) & Withers Lab (https://www.msl.ubc.ca/people/dr-stephen-withers/). This position is supported by funding from the Canadian Institutes of Health Research and the US Department of Defense.

The Centre for Blood Research is a world class facility dedicated to blood research on the University of British Columbia, Vancouver campus. The CBR is a nucleus for education and training, research, and innovation in blood research, creating new knowledge, new academic and training programs, and fostering translation and innovation. UBC Michael Smith Laboratories (MSL) is an interdisciplinary research institute with field-defining research and world class faculty. Research at MSL and CBR yield biomedical technologies and therapies that advance our health and wellbeing.

The major thrust of the research program in the Kizhakkedathu lab is to understand molecular level interactions of tailored synthetic molecules and polymers with biological systems in the design of novel biomaterials and technologies for medical use. A recent focus of this interdisciplinary research program includes immunomodulation via cell surface engineering, development of universal blood cells and organs, macromolecular therapeutics and medical devices. (https://scholar.google.ca/citations?user=zL7GeOwAAAAJ&hl=en) 

A major thrust of the research program in the Withers lab is the identification and mechanistic characterisation of novel enzymes that cleave and form glycosidic bonds and the engineering of improved enzymes.  A particular recent focus has been on the discovery and development of enzymes for removal or modification of cell surface sugar antigens to generate universal blood cells and organs. Discovery approaches include metagenomic screening, synthetic gene libraries and genome-guided explorations.  (https://scholar.google.ca/citations?user=28-Qs-UAAAAJ&hl=en).  

Position: Postdoctoral Fellow in Drug Eluting Devices

• Competitive candidates must hold a PhD in Chemistry, Polymer Chemistry, Biomedical Engineering or related area of expertise.
• Candidates with a strong background in polymer surface modification and surface analysis, drug delivery, biomaterials, polymers, and drug conjugation techniques will be considered.
• Additional experience in working with biomedical devices will be an asset.
• Experience in working with animals will be an added asset.

General Qualifications

• Candidates should have a strong research background, as demonstrated by past publications, accomplishments, and references.
• The successful candidate will be a passionate, self-driven, independent thinker with excellent organizational, oral, and written communication, excellent interpersonal skills, and a strong work ethic.
• Candidate should have a strong passion to work in an interdisciplinary research environment.

Supervision received

The incumbent will receive supervision directly from Dr. Jayachandran N Kizhakkedathu or Dr. Stephen Withers or jointly.

Supervision Given

The incumbent will be required to supervise graduate students and technicians in the research program.

Start Date and Stipend

The anticipated start date is March 15th, 2022, or upon a date to be mutually agreed; funding has already been received, and the salary will be commensurate with qualifications and experience. While this position is funded by federal agencies, the successful applicant will be expected to apply for external fellowship funding. The position is full-time for one year with the possibility of extension subject to funding availability and work performance. The funding package consists of a stipend and benefits.

Review of the applications will start on March 15th and will continue until the position is filled.

For any inquiries regarding this position, please contact Dr. Jayachandran N Kizhakkedathu (jay@pathology.ubc.ca) or Dr. Stephen G. Withers (withers@chem.ubc.ca)

Candidates should provide a CV, names and contact information for 3 references, and a cover letter describing past achievements and future research interests.

To apply visit: https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/job/UBC-Vancouver-Campus/Postdoctoral-Research-Fellow—Drug-Eluting-Devices_JR6312

Position: Postdoctoral Research Fellow in Blood Filtration Devices

The Kizhakkedathu and Withers laboratories at the University of British Columbia (UBC) in Vancouver, BC, Canada invite applications for a postdoctoral research fellow position (Kizhakkedathu Lab (https://cbr.ubc.ca/our-people/investigators/jayachandran-kizhakkedathu/) & Withers Lab (https://www.msl.ubc.ca/people/dr-stephen-withers/). This position is supported by funding from the Canadian Institutes of Health Research and the US Department of Defense.

The Centre for Blood Research is a world class facility dedicated to blood research on the University of British Columbia, Vancouver campus. The CBR is a nucleus for education and training, research, and innovation in blood research, creating new knowledge, new academic and training programs, and fostering translation and innovation. UBC Michael Smith Laboratories (MSL) is an interdisciplinary research institute with field-defining research and world class faculty.  Research at MSL and CBR yield biomedical technologies and therapies that advance our health and wellbeing.

The major thrust of the research program in the Kizhakkedathu lab is to understand molecular level interactions of tailored synthetic molecules and polymers with biological systems in the design of novel biomaterials and technologies for medical use. A recent focus of this interdisciplinary research program includes immunomodulation via cell surface engineering, development of universal blood cells and organs, macromolecular therapeutics and medical devices (https://scholar.google.ca/citations?user=zL7GeOwAAAAJ&hl=en) 

A major thrust of the research program in the Withers lab is the identification and mechanistic characterisation of novel enzymes that cleave and form glycosidic bonds and the engineering of improved enzymes.  A particular recent focus has been on the discovery and development of enzymes for removal or modification of cell surface sugar antigens to generate universal blood cells and organs. Discovery approaches include metagenomic screening, synthetic gene libraries and genome-guided explorations.  (https://scholar.google.ca/citations?user=28-Qs-UAAAAJ&hl=en).  

Qualifications:

• Competitive candidates must hold a PhD in Chemistry, Biomedical Engineering or a related area of expertise.
• Candidates with a strong background in surface modification and surface analysis, polymers, biomaterials, polymers, and protein conjugation techniques will be considered.
• Additional experience in working with blood and with blood-compatible devices will be an asset.

General Qualifications

• Candidates should have a strong research background, as demonstrated by past publications, accomplishments, and references.
• The successful candidate will be a passionate, self-driven, independent thinker with excellent organizational, oral, and written communication, excellent interpersonal skills, and a strong work ethic.
• Candidate should have a strong passion to work in an interdisciplinary research environment.

Supervision received

The incumbent will receive supervision directly from Dr. Jayachandran N Kizhakkedathu or Dr. Stephen Withers or jointly.

Supervision Given

The incumbent will be required to supervise graduate students and technicians in the research program.

Start Date and Stipend

The anticipated start date is March 15th, 2022, or upon a date to be mutually agreed; funding has already been received, and the salary will be commensurate with qualifications and experience. While this position is funded by federal agencies, the successful applicant will be expected to apply for external fellowship funding. The position is full-time for one year with the possibility of extension subject to funding availability and work performance. The funding package consists of a stipend and benefits.

Review of the applications will start on March 15th and will continue until the position is filled.

For any inquiries regarding this position, please contact Dr. Jayachandran N Kizhakkedathu (jay@pathology.ubc.ca) or Dr. Stephen G. Withers (withers@chem.ubc.ca )

Candidates should provide a CV, names and contact information for 3 references, and a cover letter describing past achievements and future research interests.

To apply visit: https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/job/UBC-Vancouver-Campus/Postdoctoral-Research-Fellow—Blood-Filtration-Devices_JR6313 

Postdoctoral Research Fellow – Macromolecular Therapeutics Targeting Immunothrombosis

The Kizhakkedathu and Withers laboratories at the University of British Columbia (UBC) in Vancouver, BC, Canada invite applications for multiple postdoctoral research fellow positions (Kizhakkedathu Lab (https://cbr.ubc.ca/our-people/investigators/jayachandran-kizhakkedathu/) & Withers Lab (https://www.msl.ubc.ca/people/dr-stephen-withers/). This position is supported by funding from the Canadian Institutes of Health Research and the US Department of Defense.

The Centre for Blood Research is a world class facility dedicated to blood research on the University of British Columbia, Vancouver campus. The CBR is a nucleus for education and training, research, and innovation in blood research, creating new knowledge, new academic and training programs, and fostering translation and innovation. UBC Michael Smith Laboratories (MSL) is an interdisciplinary research institute with field-defining research and world class faculty. Research at MSL and CBR yield biomedical technologies and therapies that advance our health and wellbeing.

The major thrust of the research program in the Kizhakkedathu lab is to understand molecular level interactions of tailored synthetic molecules and polymers with biological systems in the design of novel biomaterials and technologies for medical use. A recent focus of this interdisciplinary research program includes immunomodulation via cell surface engineering, development of universal blood cells and organs, macromolecular therapeutics and medical devices. (https://scholar.google.ca/citations?user=zL7GeOwAAAAJ&hl=en) 

A major thrust of the research program in the Withers lab is the identification and mechanistic characterisation of novel enzymes that cleave and form glycosidic bonds and the engineering of improved enzymes.  A particular recent focus has been on the discovery and development of enzymes for removal or modification of cell surface sugar antigens to generate universal blood cells and organs. Discovery approaches include metagenomic screening, synthetic gene libraries and genome-guided explorations.  (https://scholar.google.ca/citations?user=28-Qs-UAAAAJ&hl=en).  

Position:  Postdoctoral Fellow in Macromolecular Therapeutics Targeting Immunothrombosis

• Competitive candidates must hold a PhD in Chemistry, Polymer Chemistry, Biochemistry or related area of expertise.
• Candidates with a strong background in synthesis, organic synthesis, bioanalysis and conjugation techniques will be considered.
• Additional experience in the development of blood-compatible polymers will be an asset.
• Experience in animal experimentation will be an added asset
• Experience in working with blood and blood assays will be an added asset

General Qualifications

• Candidates should have a strong research background, as demonstrated by past publications, accomplishments, and references.
• The successful candidate will be a passionate, self-driven, independent thinker with excellent organizational, oral, and written communication, excellent interpersonal skills, and a strong work ethic.
• Candidate should have a strong passion to work in an interdisciplinary research environment.

Supervision received

The incumbent will receive supervision directly from Dr. Jayachandran N Kizhakkedathu or Dr. Stephen Withers or jointly.

Supervision Given

The incumbent will be required to supervise graduate students and technicians in the research program.

Start Date and Stipend

The anticipated start date is March 15th, 2022, or upon a date to be mutually agreed; funding has already been received, and the salary will be commensurate with qualifications and experience. While this position is funded by federal agencies, the successful applicant will be expected to apply for external fellowship funding. The position is full-time for one year with the possibility of extension subject to funding availability and work performance. The funding package consists of a stipend and benefits.

Review of the applications will start on March 15th and will continue until the position is filled.

For any inquiries regarding this position, please contact Dr. Jayachandran N Kizhakkedathu (jay@pathology.ubc.ca) or Dr. Stephen G. Withers (withers@chem.ubc.ca)

Candidates should provide a CV, names and contact information for 3 references, and a cover letter describing past achievements and future research interests.

To apply visit: https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/job/UBC-Vancouver-Campus/Postdoctoral-Research-Fellow—Macromolecular-Therapeutics-Targeting-Immunothrombosis_JR6314

Position: Postdoctoral Research Fellow in Enzyme Engineering

The Kizhakkedathu and Withers laboratories at the University of British Columbia (UBC) in Vancouver, BC, Canada invite applications for multiple postdoctoral research fellow positions (Kizhakkedathu Lab (https://cbr.ubc.ca/our-people/investigators/jayachandran-kizhakkedathu/) & Withers Lab (https://www.msl.ubc.ca/people/dr-stephen-withers/). This position are supported by funding from the Canadian Institutes of Health Research and the US Department of Defense.

The Centre for Blood Research is a world class facility dedicated to blood research on the University of British Columbia, Vancouver campus. The CBR is a nucleus for education and training, research, and innovation in blood research, creating new knowledge, new academic and training programs, and fostering translation and innovation. UBC Michael Smith Laboratories (MSL) is an interdisciplinary research institute with field-defining research and world class faculty. Research at MSL and CBR yield biomedical technologies and therapies that advance our health and wellbeing.

The major thrust of the research program in the Kizhakkedathu lab is to understand molecular level interactions of tailored synthetic molecules and polymers with biological systems in the design of novel biomaterials and technologies for medical use. A recent focus of this interdisciplinary research program includes immunomodulation via cell surface engineering, development of universal blood cells and organs, macromolecular therapeutics and medical devices. (https://scholar.google.ca/citations?user=zL7GeOwAAAAJ&hl=en) 

A major thrust of the research program in the Withers lab is the identification and mechanistic characterisation of novel enzymes that cleave and form glycosidic bonds and the engineering of improved enzymes.  A particular recent focus has been on the discovery and development of enzymes for removal or modification of cell surface sugar antigens to generate universal blood cells and organs. Discovery approaches include metagenomic screening, synthetic gene libraries and genome-guided explorations.  (https://scholar.google.ca/citations?user=28-Qs-UAAAAJ&hl=en).  

Position: Postdoctoral Research Fellow in Enzyme Engineering

• Competitive candidates must hold a PhD in Biochemistry, Molecular Biology, Chemistry or a related area of expertise.
• Candidates with a strong background in gene cloning, genetic engineering, protein purification, enzymology and glycoscience will be considered.
• Experience in, and knowledge of, glycobiology and/or carbohydrate chemistry will be an asset.
• Experience in high-throughput screening and/or metagenomic studies will be a further asset.

General Qualifications

• Candidates should have a strong research background, as demonstrated by past publications, accomplishments, and references.
• The successful candidate will be a passionate, self-driven, independent thinker with excellent organizational, oral, and written communication, excellent interpersonal skills, and a strong work ethic.
• Candidate should have a strong passion to work in an interdisciplinary research environment.

Supervision received

The incumbent will receive supervision directly from Dr. Jayachandran N Kizhakkedathu or Dr. Stephen Withers or jointly.

Supervision Given

The incumbent will be required to supervise graduate students and technicians in the research program.

Start Date and Stipend

The anticipated start date is March 15th, 2022, or upon a date to be mutually agreed; funding has already been received, and the salary will be commensurate with qualifications and experience. While this position is funded by federal agencies, the successful applicant will be expected to apply for external fellowship funding. The position is full-time for one year with the possibility of extension subject to funding availability and work performance. The funding package consists of a stipend and benefits.

Review of the applications will start on March 15th and will continue until the position is filled.

For any inquiries regarding this position, please contact Dr. Jayachandran N Kizhakkedathu (jay@pathology.ubc.ca) or Dr. Stephen G. Withers (withers@chem.ubc.ca)

Candidates should provide a CV, names and contact information for 3 references, and a cover letter describing past achievements and future research interests. 

To apply visit: https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/job/UBC-Vancouver-Campus/Postdoctoral-Research-Fellow—Enzyme-Engineering_JR6315

The Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, invites applications for The Iris and George Brown Postdoctoral Fellow in Next-Generation RNA Therapeutics. The successful Postdoctoral Fellow (PDF) candidate will join a dynamic and multidisciplinary team under the supervision of Dr. Anna Blakney. The successful candidate will work on a project to develop self-amplifying RNA therapies encoding monoclonal antibodies. The Blakney Lab at UBC (blakneylab.msl.ubc.ca) develops next-generation RNA vaccines and therapies based on self-amplifying RNA and using interdisciplinary approaches including bioengineering, immunology, molecular biology and bioinformatics.

Project: Monoclonal antibodies are highly potent and specific biologic drugs that have revolutionized treatment of cancer and rare diseases. However, they generally require intravenous administration and are costly, which prohibits widespread global use for applications such as prevention of infectious disease. Our goal is to develop self-amplifying RNA formulations that are able to achieve systemic, therapeutically relevant levels of monoclonal antibodies that are able to be injected intramuscularly. We anticipate that this technology will expand global access to antibody therapies that are more equitable.

Candidate: We are hiring post-doctoral bioengineers with a background in antibody design, molecular biology, RNA gene therapies and/or biomaterials. Candidates must have a Ph.D. in biomedical engineering, chemical engineering, molecular biology, chemistry, or similar fields. The candidate must be able to work well on a team, even in situations where an opportunity is more exciting and time-sensitive than normal. We are seeking a creative individual with great interpersonal skills and excellent communication, both written and verbal.

Opportunity: This is a unique opportunity for several reasons. First, you will be a member of a fun, diverse and interdisciplinary group. Second, you will learn about RNA gene therapies. Third, you will be actively involved in projects that are intended for clinical translation. Finally, the University of British Columbia is located in Vancouver, which is world-renowned for its scenery and quality of living. UBC is a center of excellence for growing your career in nanomedicine and gene delivery technologies, and you will have opportunities to collaborate with world-class leaders in the field, such as the Cullis Laboratory, through the Nanomedicine Innovation Network.

Application Process: Interested applicants should submit a CV and cover letter that details their experience and contact details for 3 references. Applications should be submitted to anna.blakney@msl.ubc.ca with ‘PDF saRNA mAbs’ in the email subject line. Applicants for the position will be evaluated in the order they are received.

This posting will remain open until the position is filled. The proposed start date for this position is March 2022 and is negotiable. The appointment will initially be for one year and is extendable depending on funding availability. Applicants are encouraged to apply for competitive fellowship awards. Salary will be commensurate with qualifications, experience and awards secured.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

Job Description Summary
The Facility Manager manages the Analytical Core Laboratory (ACL), which is a core facility within the Faculty of Land and Food Systems.  It is a stand-alone, state-of-the-art analytical laboratory housing research equipment worth over $5 Million. The Analytical Core Laboratory provides services to a large number of scientists in the Faculty of Land and Food Systems, Michael Smith Laboratory, and other scientists at UBC, as well as other institutions and industry partners.

Organizational Status
The Facility Manager works independently and reports to the Associate Dean Research (ADR), who is the Chair of the Analytical Core Committee, on day-to-day activities that are ongoing within the ACL. The Analytical Core Committee serves to steer the activities of the core facility.  The manager works closely with the FNH/WRC Administrative Manager and with internal UBC faculty members, postdoctoral fellows, visitors and graduate students that have committed projects with the ACL. This position liaises with external vendors and user groups. 

Click here to view the job posting: https://ubc.wd10.myworkdayjobs.com/ubcstaffjobs/job/UBC-Vancouver-Campus/Facility-Manager–LFS-Analytical-Core-Laboratory_JR5674. 

The closing date for this job posting is 11:59 pm on Sunday, January 9^th. 

We encourage all qualified candidates to apply.

Dr. Sabrina Leslie at UBC Michael Smith Laboratories is recruiting a graduate student with interest in biophysics and nanomedicines. Our group develops and utilizes single-molecule fluorescence microscopy techniques to study lipid nanoparticle loading and delivery of biomolecules in cell-like environments. We’ve developed the Convex Lens-induced Confinement (CLiC) imaging platform, which makes it possible to watch individual, freely diffusing biomolecules/ nanoparticles as they search for and bind to each other, allowing us to make measurements that are not possible with other methods. This technique is applied both to basic biophysical research and development of drugs and therapeutics.

Project: Nanoparticle analytics

This project will study the structure and structural transitions of nanoparticles in controlled environments, to help develop nanoparticle-based drug delivery platforms. Nanoparticles are an emerging technology used to encapsulate drugs for delivery into the body. Upon an environmental shift, the structure of the nanoparticle changes, releasing the drug. The goal of this research will be to characterize these dynamics and understand drug delivery mechanisms.

Training: Graduate students in the Leslie Lab receive training in single-molecule microscopy, specializing in the CLiC imaging technique pioneered in our lab; bulk characterization techniques such as Dynamic Light Scattering, fluorimetry, and gel electrophoresis; and computational modelling and analysis. The candidates will work with sophisticated DNA/RNA constructs as well as complex lipid nanoparticle formulations, with exposure to molecular design of oligotherapeutic compounds and biomimetic delivery vehicles. The training environment will include interactions with a start-up company, ScopeSys Inc., which is commercializing CLiC technology; as well as collaborators in pharmaceutical science, biochemistry and medicine.

We are looking for a well-organized, enthusiastic team player who enjoys lab work and troubleshooting scientific instrumentation. Background/training in biochemistry, quantitative biology, pharmaceutical sciences or surface chemistry is an asset. Proficiency with a musical instrument and/or dungeons and dragons are also assets. The successful candidates must have a passion for innovation and pushing scientific and engineering capabilities to the forefront of what is possible today.

To apply, please send a cover letter and CV to leslielab [at] msl.ubc.ca.

Dr. Sabrina Leslie at UBC Michael Smith Laboratories is recruiting a graduate student with interest in biophysics, nanoscience, biotechnology, engineering and computational analysis. Our group develops and utilizes single-molecule fluorescence microscopy techniques to study interactions of biomolecules in cell-like environments. We’ve developed the Convex Lens-induced Confinement (CLiC) imaging platform, which makes it possible to watch individual, naturally fluctuating biomolecules as they search for and bind to each other, allowing us to make measurements that are not possible with other methods. This technique is applied both to basic biophysical research and development of drugs and therapeutics.

Project: Oligonucleotide therapeutics

Antisense oligonucleotides (ASOs) are an emerging treatment for genetic diseases. They are snippets of modified DNA designed to bind to mRNA produced by a detrimental gene and targeting it for destruction. The goal of this research project will be to characterize ASO-mRNA binding dynamics to improve drug and treatment development.

Training: Graduate students in the Leslie Lab receive training in single-molecule microscopy specializing in the CLiC imaging technique pioneered in our lab, bulk characterization techniques such as Dynamic Light Scattering, fluorimetry, spectrophotometry, and gel electrophoresis, and computational modelling and analysis. The candidates will work with sophisticated DNA/RNA constructs as well as complex lipid nanoparticle formulations, with exposure to molecular design of oligotherapeutic compounds and biomimetic delivery vehicles. The training environment will include interactions with a start-up company, ScopeSys Inc., which is commercializing CLiC technology; as well as collaborators in pharmaceutical science, biochemistry and medicine.

Interested candidate should have a degree in physics, engineering, or biophysics, with passion for lab work and troubleshooting scientific instrumentation, and is creative, versatile and well-organized. Strong interest in optics and instrumentation is an asset. Proficiency with a musical instrument and/or dungeons and dragons are also assets. The successful candidates must have a passion for innovation and pushing scientific and engineering capabilities to the forefront of what is possible today.

To apply, please send a cover letter and CV to leslielab [at] msl.ubc.ca

Dr. Sabrina Leslie at UBC Michael Smith Laboratories is recruiting a graduate student with interest in biophysics, nanoscience and biology. Our group develops and utilizes single-molecule fluorescence microscopy techniques to study interactions of biomolecules in cell-like environments. We’ve developed the Convex Lens-induced Confinement (CLiC) imaging platform, which makes it possible to watch individual, naturally fluctuating biomolecules as they search for and bind to each other, allowing us to make measurements that are not possible with other methods. This technique is applied both to basic biophysical research and development of drugs and therapeutics.

Project: Effects of topology on DNA structure and interactions

DNA supercoiling drives structural transitions within a DNA molecule. This project will study the dynamics of such transitions, how multiple transitions within the same molecule can compete with one another, and how such transitions affect protein-DNA interactions. The goal of the research project will be to better understand the role of these structural transitions in gene regulation and bridge the gap between in vitro and live cell studies.

Training: Graduate students in the Leslie Lab receive training in single-molecule microscopy, specializing in the CLiC imaging technique pioneered in our lab; bulk characterization techniques such as Dynamic Light Scattering, and fluorimetry; standard molecular biology techniques including cell transformation, and gel electrophoresis; and computational modelling, image processing and analysis. The training environment will include interactions with a start-up company, ScopeSys Inc., which is commercializing CLiC technology; as well as collaborators in pharmaceutical science, biochemistry and medicine.

We are looking for a well-organized, enthusiastic team player who enjoys lab work and troubleshooting scientific instrumentation. A successful candidate would have experience with or interest in DNA structure and function, fluorescence microscopy, statistical mechanics, mathematical modelling, and computer programming. Background in biophysics, molecular genetics, quantitative biology, or a related field is an asset. Proficiency with a musical instrument and/or dungeons and dragons are also assets. The successful candidates must have a passion for innovation and pushing scientific and engineering capabilities to the forefront of what is possible today.

To apply, please send a cover letter and CV to leslielab [at] msl.ubc.ca.

The Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, invites applications for a Postdoctoral Fellow (PDF) to join a dynamic team under the supervision of Dr. Sabrina Leslie. The successful candidate will work on a project that applies new biophysical tools to the development of genetic medicines and vaccines. The position is based in a cutting-edge academic research lab and the project will be driven by real and immediate needs, in collaboration with interdisciplinary scientists in the Nanomedicine Center of Excellence (NMIN).

About the high-throughput single-molecule CLiC imaging technology
The Leslie Lab’s single-molecule technology, Convex Lens-induced Confinement (CLiC), works by squeezing molecules into arrays of nanometer- to micrometer-scale “traps” that are large enough to allow the molecules to move and interact freely, but small enough to keep them confined so they can be imaged over extended periods with a high-powered optical microscope. The result is the world’s first tether-free and high-throughput single-molecule technology for analyzing individual molecular interactions in cell-like conditions. CLiC is capable of detecting, following, and understanding rare molecular events – like the drug/target interactions which can ‘silence’ genes associated with the onset of diseases – and by enabling direct visualization of how the drugs work, help us better engineer them.

About the position
The PDF will join a talented, energetic, interdisciplinary team of scientists and engineers working in a newly built laboratory. Our team collaborates with the spin-off company ScopeSys to respond to partnerships with leading drug and vaccine development research groups and companies. The emphasis of this position will be on applications of our single-molecule and single-cell imaging technology to improve and accelerate development of lipid-nanoparticle and RNA-based medicines and vaccines.

This project will require an interdisciplinary skill set, combining physical, chemical and biological expertise. The ideal candidate will possess experience and interest in some of the following areas:

• Microscopy of molecules, nanomaterials, cells
• Instrumentation, optics, engineering
• Micro/nano-fabrication and lithography
• Surface science and chemistry
• DNA, RNA, lipid nanoparticles, cells
• Biophysical assay and protocol development
• Electronics, mechanical engineering, machining

The successful candidate will have a PhD and a demonstrated track record in research with first authored peer-review publications. The position will be filled by a well-organized, enthusiastic team player with strong communication skills, who enjoys hands-on lab work and creative trouble-shooting, and who is excited to try new things. Applicants should have a strong interest in building a career in biotechnology and/or nanotechnology research and development, pioneering new biophysical techniques, and commercializing cutting edge science and technology.

Application process
Interested applicants should submit a letter of application that highlights their experience, detailed curriculum vitae including a list of publications, and contact details for 3 references. Application materials should be combined into a single PDF document and sent to leslielab@msl.ubc.ca. Please include “PDF in single-molecule biophysics and biotechnology” in the e-mail subject line. Incorrectly addressed applications will not be considered. Review of applications will begin immediately and continue until the position is filled. We will contact you only if invited for an interview.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.