Current Positions

The Michael Smith Laboratories at the University of British Columbia (UBC) invites applications for a faculty position in Plant Bioengineering. The anticipated rank is Assistant Professor. The anticipated start date is September 1, 2022 or as soon as possible thereafter.

The Michael Smith Laboratories (MSL; https://www.msl.ubc.ca/) is a dynamic hub for groundbreaking biotechnology research and education excellence. Our highly interdisciplinary and collaborative research environment supports faculty with focus in genomics, molecular biology, engineering, and biotechnology. More than 300 faculty, postdocs, students, and research personnel make the MSL their home with appointments across the Faculty of Science, Medicine, Applied Science, Forestry, Land and Food Systems, and Pharmaceutical Science. The MSL has a proven record of accomplishment in fundamental and applied research that has led to transformative impacts for Canada and the world.

This is a broad search for candidates in the area of plant bioengineering. The successful candidates will be expected to lead an independent research program of international caliber. Plant bioengineering related areas of strategic interests include, but are not limited to high value plant bioproducts, plant synthetic biology, and food security. The candidate will be expected to contribute excellence in undergraduate and graduate teaching in appropriate partner departments, effectively supervise graduate students, provide service within the MSL and the University, and be prepared to integrate their expertise with other innovative researchers at the University’s Vancouver and Okanagan campuses.

Applicants are expected to have a Ph.D. or equivalent, with demonstrated outstanding research strength and creativity, a track record of success in collaborative team-based approach to tackling big problems in science and engineering, and demonstrated potential for excellent graduate and undergraduate teaching.

Salary will be commensurate with qualifications and experience.

Applicants should submit a curriculum vitae, a statement of teaching interests and accomplishments (1-2 pages), a five-year research program plan (up to 4 pages), the names and contact information of four referees (1 page), and a statement describing their experience working with a diverse student body, and contributions to creating/advancing a culture of equity and inclusion on campus or within their discipline (1 page). Application materials should be combined into a single PDF document and be uploaded to https://academicjobsonline.org/ajo/jobs/20254.

Applicants will be asked to complete an equity survey. The survey information will not be used to determine eligibility for employment, but will be collated to provide data that can assist us in understanding the diversity of our applicant pool and identifying potential barriers to the employment of designated equity group members. Your participation in the survey is voluntary and confidential.

Review of applications will begin January 31, 2022.

The University of British Columbia is a global centre for research and teaching, consistently ranked among the top 20 public universities in the world and 3rd largest university in Canada with an economic impact of 12.5 billion to the provincial economy. Since 1915, UBC’s West Coast spirit has embraced innovation and challenged the status quo. Its entrepreneurial perspective encourages students, staff and faculty to challenge convention, lead discovery and explore new ways of learning. At UBC, bold thinking is given a place to develop into ideas that can change the world. As one of the world’s leading universities, The University of British Columbia creates an exceptional learning environment that fosters global citizenship, advances a civil and sustainable society, and supports outstanding research to serve the people of British Columbia, Canada and the world.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person. All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority

The Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, invites applications for The Iris and George Brown Postdoctoral Fellow in Next-Generation RNA Therapeutics. The successful Postdoctoral Fellow (PDF) candidate will join a dynamic and multidisciplinary team under the supervision of Dr. Anna Blakney. The successful candidate will work on a project to develop self-amplifying RNA therapies encoding monoclonal antibodies. The Blakney Lab at UBC (blakneylab.msl.ubc.ca) develops next-generation RNA vaccines and therapies based on self-amplifying RNA and using interdisciplinary approaches including bioengineering, immunology, molecular biology and bioinformatics.

Project: Monoclonal antibodies are highly potent and specific biologic drugs that have revolutionized treatment of cancer and rare diseases. However, they generally require intravenous administration and are costly, which prohibits widespread global use for applications such as prevention of infectious disease. Our goal is to develop self-amplifying RNA formulations that are able to achieve systemic, therapeutically relevant levels of monoclonal antibodies that are able to be injected intramuscularly. We anticipate that this technology will expand global access to antibody therapies that are more equitable.

Candidate: We are hiring post-doctoral bioengineers with a background in antibody design, molecular biology, RNA gene therapies and/or biomaterials. Candidates must have a Ph.D. in biomedical engineering, chemical engineering, molecular biology, chemistry, or similar fields. The candidate must be able to work well on a team, even in situations where an opportunity is more exciting and time-sensitive than normal. We are seeking a creative individual with great interpersonal skills and excellent communication, both written and verbal.

Opportunity: This is a unique opportunity for several reasons. First, you will be a member of a fun, diverse and interdisciplinary group. Second, you will learn about RNA gene therapies. Third, you will be actively involved in projects that are intended for clinical translation. Finally, the University of British Columbia is located in Vancouver, which is world-renowned for its scenery and quality of living. UBC is a center of excellence for growing your career in nanomedicine and gene delivery technologies, and you will have opportunities to collaborate with world-class leaders in the field, such as the Cullis Laboratory, through the Nanomedicine Innovation Network.

Application Process: Interested applicants should submit a CV and cover letter that details their experience and contact details for 3 references. Applications should be submitted to anna.blakney@msl.ubc.ca with ‘PDF saRNA mAbs’ in the email subject line. Applicants for the position will be evaluated in the order they are received.

This posting will remain open until the position is filled. The proposed start date for this position is March 2022 and is negotiable. The appointment will initially be for one year and is extendable depending on funding availability. Applicants are encouraged to apply for competitive fellowship awards. Salary will be commensurate with qualifications, experience and awards secured.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

Job Summary: The Lab Manager manages day-to-day research operations, financial and personnel activities for a single-molecule biophysics and biotechnology lab at the MSL. The incumbent will work closely with the Principal Investigator for guidance on developing and submitting research grant proposals, developing budgets and financial projections, personnel appointments, onboarding/ offboarding of new members, and general running of the laboratory.

Organizational Status: This position reports directly to the Principle Investigator, Dr. Sabrina Leslie. The Lab Manager will join a team of interdisciplinary scientists whose research focuses on pioneering tether-free, high-throughput, super-high-resolution imaging technologies for basic research on DNA/RNA/protein interactions and therapeutics. This includes daily interactions with the Principle Investigator and approximately 15 lab members (post docs, graduate and undergraduate students). The Lab Manager will serve as the lab contact within and outside the University.

Work Performed:

• Manages the research laboratory finances including budget forecasting, preparing comprehensive financial reports and statements, resolves discrepancies and directs the transfer of funds as necessary.
• Responsible for the daily operations of the research laboratory, personnel onboarding, communicate lab safety guidelines, maintains laboratory infrastructure and supply inventories, and oversees equipment repairs.
• Provides recommendations to the Principal Investigator with regards to research expenses, recruitment of trainees, and other related activities.
• Identifies, develops, prepares, edits and proofs documents, including research grant applications, reporting documentation for funding agencies, student reports, manuscripts, fellowship applications, sponsored research agreements and other contracts with non-academic research collaborators.
• Develops relationships with suppliers and negotiates equipment and supplies purchases in consultation with the PI and other senior members of the lab.
• Identifies and implements strategies and procedures to ensure the safe operation of the research laboratory. Ensures compliance with safety regulations in the lab.
• Coordinates meetings for research team and other project meetings.
• Hires new trainees and staff, including writing job descriptions, interviewing, onboarding and other related tasks.
• Facilitates reappointments for staff and students with department HR and provide feedback on staff performance for hiring and retention decisions.
• Maintains lab websites, troubleshoots errors.
• Develops standard operating procedures for research methodology with support from lab scientists.
• Acts as the laboratory representative in a liaison capacity with other research laboratories, outside agencies, institutions and industrial companies.
• Carries out any other related duties as required in keeping with the qualifications and requirements of positions in this classification.

Consequence of Error: Exercises excellent judgement, responsibility and initiative in performing financial and administrative tasks. Errors in managing the laboratory financial resources could result in over-expenditure of the project grants that could compromise funding, consequently impacting the research and the credibility of the Principle Investigator. The candidate will demonstrate discretion and tact when handling sensitive information relating to trainees and staff.

Supervision Received: Works under minimum supervision and sets own priorities based on workload. Receives specific instructions only on matters which depart from established policy and procedure or has significant financial implications. Will exercise judgment in the execution of laboratory maintenance, purchasing of supplies, and in the hiring and supervision of undergraduate students.

Supervision Given: Provides guidance and direction to students, faculty and staff.

Qualifications: Undergraduate in a relevant discipline. Minimum of two years of related experience or the equivalent combination of education and experience. Preference will be given to training in the field of biotechnology, bioengineering, biomedical engineering, biophysics, physics, chemistry or biochemistry. Complementary training in management, finance, visual arts, or a communication related discipline are appreciated. Demonstrated experience with leadership or management in the form of work, extracurricular, or volunteer experience is an asset. Knowledge and experience with scientific research, research budget management, hiring, task prioritization, project management, as well as a knowledge of university systems, policies and procedures are assets.

Technical knowledge and training in scientific instrumentation, and applications of imaging technology to health and biological research are valuable for this position.

• Ability to maintain accuracy and attention to detail, whilst not losing focus on the big picture.
• Ability to analyze problems, identify key information and issues, and contribute to solutions.
• Ability to develop and maintain cooperative and productive working relationships.
• Ability to empathize, demonstrate patience and adapt to a wide range of people.
• Effective oral and written communication skills.

Demonstrate initiative in determining work priorities and meet deadlines, while having flexibility and responsiveness to changing needs.

How to Apply: For details, please visit https://ubc.wd10.myworkdayjobs.com/ubcstaffjobs/job/UBC-Vancouver-Campus/Lab-Manager_JR5844-1

The University of British Columbia is seeking four outstanding Immunologists for Research Associate positions. These are unique positions where the Research Associates will be employed by the University of British Columbia (UBC) through a collaborative research agreement with Eyam Vaccines and Immunotherapeutic (EYAM). This relationship will present an opportunity to experience collaborative research with leading industry and academic experts. Under the direction of Dr. Wilf Jefferies at UBC’s Michael Smith Laboratories, the Research Associates will design and conduct immune assays to measure immune responses from immunizations for COVID-19, other infectious diseases, neurodegenerative diseases and cancers. These lab-based positions are a great opportunity to conduct preclinical assays that will help validate vaccine candidates for clinical development. The Research Associates will act as a mentor for junior scientists and postdoctoral fellows, working collaboratively with the Research and Development team at EYAM and the academic research team at UBC.

Qualifications

• PhD in Immunology, Microbiology (Virology), Cancer Immunology, Cell Biology or other related fields or MSc. with 5+ years experience in virology and immunological assays in an academic or industry wet laboratory environment
• 3+ years of postdoctoral (or equivalent) independent research experience
• Working experience in biosafety containment level CL2 (required) and CL3 (ideal)laboratories
• Working experience with infectious disease and/or cancer mouse models
• Working knowledge and experience of cell-culturing, flow-cytometry, tetramer assays, molecular techniques and animal tissue and serum extraction
• Self-motivated and works independently
• Strong interpersonal skills with the ability to work collaboratively
• Excellent documentation and organizational skills
• Strong verbal and written communication skills

How to Apply

Interested applicants should submit a letter of application that highlights their experience, detailed curriculum vitae including a list of publications, and contact details for 3 references. Application materials should be submitted to the UBC Careers portal at https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/job/UBC-Vancouver-Campus/Research-Associate—Immunology_JR5740. We will only be in contact with applicants invited for an interview but we thank you in advance for you time put into your application.

The appointment will initially be one year with salary commensurate with qualifications and experience, extendable depending on funding availability.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadian citizens and permanent residents will be given priority.

The University of British Columbia is seeking an outstanding Scientist for a Research Associate position. This is a unique posting where the Research Associate will be employed by the University of British Columbia (UBC) through a collaborative research agreement with Eyam Vaccines and Immunotherapeutic (EYAM). This relationship will present an opportunity to experience collaborative research with leading industry and academic experts. Under the direction of Dr. Wilf Jefferies at UBC’s Michael Smith Laboratories, the Research Associate will design and conduct molecular biology and immunology assays to test the biological performance and efficacy of vaccines and immunotherapeutics. This lab-based position is a great opportunity to conduct discovery phase research and preclinical assays that will help validate vaccine and immunotherapeutic candidates for clinical development. The Research Associate will be passionate and knowledgeable about vaccine design and function and will have a strong interest to improve vaccine performance.

The Research Associate will play an integral role in the development of a rapidly growing research program and will act as a mentor for junior scientists and postdoctoral fellows. They will work collaboratively with the Research and Development team at EYAM and the academic research team at UBC.

Qualifications and skills

• PhD in Immunology, Microbiology (Virology), Molecular Biology or other related fields or MSc. with 5+ years experience in virology and immunological assays in an academic or industry wet laboratory environment
• 3+ years of postdoctoral (or equivalent) independent research experience in vaccine design, molecular biology, virology, cancer immunology and/or infectious diseases (SARSCoV2 and Influenza)
• Working experience in biosafety containment level CL2 (required) and CL3 (ideal) laboratories
• Project management experience for vaccine clinical trials (ideal)
• Working knowledge of protein, gene, and genomics design and analysis software
• Working experience in viral vector and nucleic acid-based vaccine design
• Working experience with infectious disease rodent models
• Working knowledge and experience of cell-culturing, flow-cytometry, tetramer assays, molecular techniques and animal tissue and serum extraction
• Self-motivated and works independently
• Strong interpersonal skills with the ability to work collaboratively
• Excellent documentation and organizational skills
• Strong verbal and written communication skills

How to Apply

Interested applicants should submit a letter of application that highlights their experience, detailed curriculum vitae including a list of publications, and contact details for 3 references. Application materials should be submitted to the UBC Careers portal at https://ubc.wd10.myworkdayjobs.com/en-US/ubcfacultyjobs/job/UBC-Vancouver-Campus/Research-Associate—Vaccine-Development_JR5645

We will only be in contact with applicants invited for an interview but we thank you in advance for you time put into your application.

The appointment will initially be one year with salary commensurate with qualifications and experience, extendable depending on funding availability. 

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadian citizens and permanent residents will be given priority.

Job Description Summary
The Facility Manager manages the Analytical Core Laboratory (ACL), which is a core facility within the Faculty of Land and Food Systems.  It is a stand-alone, state-of-the-art analytical laboratory housing research equipment worth over $5 Million. The Analytical Core Laboratory provides services to a large number of scientists in the Faculty of Land and Food Systems, Michael Smith Laboratory, and other scientists at UBC, as well as other institutions and industry partners.

Organizational Status
The Facility Manager works independently and reports to the Associate Dean Research (ADR), who is the Chair of the Analytical Core Committee, on day-to-day activities that are ongoing within the ACL. The Analytical Core Committee serves to steer the activities of the core facility.  The manager works closely with the FNH/WRC Administrative Manager and with internal UBC faculty members, postdoctoral fellows, visitors and graduate students that have committed projects with the ACL. This position liaises with external vendors and user groups. 

Click here to view the job posting: https://ubc.wd10.myworkdayjobs.com/ubcstaffjobs/job/UBC-Vancouver-Campus/Facility-Manager–LFS-Analytical-Core-Laboratory_JR5674. 

The closing date for this job posting is 11:59 pm on Sunday, January 9^th. 

We encourage all qualified candidates to apply.

Dr. Sabrina Leslie at UBC Michael Smith Laboratories is recruiting a graduate student with interest in biophysics and nanomedicines. Our group develops and utilizes single-molecule fluorescence microscopy techniques to study lipid nanoparticle loading and delivery of biomolecules in cell-like environments. We’ve developed the Convex Lens-induced Confinement (CLiC) imaging platform, which makes it possible to watch individual, freely diffusing biomolecules/ nanoparticles as they search for and bind to each other, allowing us to make measurements that are not possible with other methods. This technique is applied both to basic biophysical research and development of drugs and therapeutics.

Project: Nanoparticle analytics

This project will study the structure and structural transitions of nanoparticles in controlled environments, to help develop nanoparticle-based drug delivery platforms. Nanoparticles are an emerging technology used to encapsulate drugs for delivery into the body. Upon an environmental shift, the structure of the nanoparticle changes, releasing the drug. The goal of this research will be to characterize these dynamics and understand drug delivery mechanisms.

Training: Graduate students in the Leslie Lab receive training in single-molecule microscopy, specializing in the CLiC imaging technique pioneered in our lab; bulk characterization techniques such as Dynamic Light Scattering, fluorimetry, and gel electrophoresis; and computational modelling and analysis. The candidates will work with sophisticated DNA/RNA constructs as well as complex lipid nanoparticle formulations, with exposure to molecular design of oligotherapeutic compounds and biomimetic delivery vehicles. The training environment will include interactions with a start-up company, ScopeSys Inc., which is commercializing CLiC technology; as well as collaborators in pharmaceutical science, biochemistry and medicine.

We are looking for a well-organized, enthusiastic team player who enjoys lab work and troubleshooting scientific instrumentation. Background/training in biochemistry, quantitative biology, pharmaceutical sciences or surface chemistry is an asset. Proficiency with a musical instrument and/or dungeons and dragons are also assets. The successful candidates must have a passion for innovation and pushing scientific and engineering capabilities to the forefront of what is possible today.

To apply, please send a cover letter and CV to leslielab [at] msl.ubc.ca.

Dr. Sabrina Leslie at UBC Michael Smith Laboratories is recruiting a graduate student with interest in biophysics, nanoscience, biotechnology, engineering and computational analysis. Our group develops and utilizes single-molecule fluorescence microscopy techniques to study interactions of biomolecules in cell-like environments. We’ve developed the Convex Lens-induced Confinement (CLiC) imaging platform, which makes it possible to watch individual, naturally fluctuating biomolecules as they search for and bind to each other, allowing us to make measurements that are not possible with other methods. This technique is applied both to basic biophysical research and development of drugs and therapeutics.

Project: Oligonucleotide therapeutics

Antisense oligonucleotides (ASOs) are an emerging treatment for genetic diseases. They are snippets of modified DNA designed to bind to mRNA produced by a detrimental gene and targeting it for destruction. The goal of this research project will be to characterize ASO-mRNA binding dynamics to improve drug and treatment development.

Training: Graduate students in the Leslie Lab receive training in single-molecule microscopy specializing in the CLiC imaging technique pioneered in our lab, bulk characterization techniques such as Dynamic Light Scattering, fluorimetry, spectrophotometry, and gel electrophoresis, and computational modelling and analysis. The candidates will work with sophisticated DNA/RNA constructs as well as complex lipid nanoparticle formulations, with exposure to molecular design of oligotherapeutic compounds and biomimetic delivery vehicles. The training environment will include interactions with a start-up company, ScopeSys Inc., which is commercializing CLiC technology; as well as collaborators in pharmaceutical science, biochemistry and medicine.

Interested candidate should have a degree in physics, engineering, or biophysics, with passion for lab work and troubleshooting scientific instrumentation, and is creative, versatile and well-organized. Strong interest in optics and instrumentation is an asset. Proficiency with a musical instrument and/or dungeons and dragons are also assets. The successful candidates must have a passion for innovation and pushing scientific and engineering capabilities to the forefront of what is possible today.

To apply, please send a cover letter and CV to leslielab [at] msl.ubc.ca

Dr. Sabrina Leslie at UBC Michael Smith Laboratories is recruiting a graduate student with interest in biophysics, nanoscience and biology. Our group develops and utilizes single-molecule fluorescence microscopy techniques to study interactions of biomolecules in cell-like environments. We’ve developed the Convex Lens-induced Confinement (CLiC) imaging platform, which makes it possible to watch individual, naturally fluctuating biomolecules as they search for and bind to each other, allowing us to make measurements that are not possible with other methods. This technique is applied both to basic biophysical research and development of drugs and therapeutics.

Project: Effects of topology on DNA structure and interactions

DNA supercoiling drives structural transitions within a DNA molecule. This project will study the dynamics of such transitions, how multiple transitions within the same molecule can compete with one another, and how such transitions affect protein-DNA interactions. The goal of the research project will be to better understand the role of these structural transitions in gene regulation and bridge the gap between in vitro and live cell studies.

Training: Graduate students in the Leslie Lab receive training in single-molecule microscopy, specializing in the CLiC imaging technique pioneered in our lab; bulk characterization techniques such as Dynamic Light Scattering, and fluorimetry; standard molecular biology techniques including cell transformation, and gel electrophoresis; and computational modelling, image processing and analysis. The training environment will include interactions with a start-up company, ScopeSys Inc., which is commercializing CLiC technology; as well as collaborators in pharmaceutical science, biochemistry and medicine.

We are looking for a well-organized, enthusiastic team player who enjoys lab work and troubleshooting scientific instrumentation. A successful candidate would have experience with or interest in DNA structure and function, fluorescence microscopy, statistical mechanics, mathematical modelling, and computer programming. Background in biophysics, molecular genetics, quantitative biology, or a related field is an asset. Proficiency with a musical instrument and/or dungeons and dragons are also assets. The successful candidates must have a passion for innovation and pushing scientific and engineering capabilities to the forefront of what is possible today.

To apply, please send a cover letter and CV to leslielab [at] msl.ubc.ca.

The Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, invites applications for a Postdoctoral Fellow (PDF) to join a dynamic team under the supervision of Dr. Sabrina Leslie. The successful candidate will work on a project that applies new biophysical tools to the development of genetic medicines and vaccines. The position is based in a cutting-edge academic research lab and the project will be driven by real and immediate needs, in collaboration with interdisciplinary scientists in the Nanomedicine Center of Excellence (NMIN).

About the high-throughput single-molecule CLiC imaging technology
The Leslie Lab’s single-molecule technology, Convex Lens-induced Confinement (CLiC), works by squeezing molecules into arrays of nanometer- to micrometer-scale “traps” that are large enough to allow the molecules to move and interact freely, but small enough to keep them confined so they can be imaged over extended periods with a high-powered optical microscope. The result is the world’s first tether-free and high-throughput single-molecule technology for analyzing individual molecular interactions in cell-like conditions. CLiC is capable of detecting, following, and understanding rare molecular events – like the drug/target interactions which can ‘silence’ genes associated with the onset of diseases – and by enabling direct visualization of how the drugs work, help us better engineer them.

About the position
The PDF will join a talented, energetic, interdisciplinary team of scientists and engineers working in a newly built laboratory. Our team collaborates with the spin-off company ScopeSys to respond to partnerships with leading drug and vaccine development research groups and companies. The emphasis of this position will be on applications of our single-molecule and single-cell imaging technology to improve and accelerate development of lipid-nanoparticle and RNA-based medicines and vaccines.

This project will require an interdisciplinary skill set, combining physical, chemical and biological expertise. The ideal candidate will possess experience and interest in some of the following areas:

• Microscopy of molecules, nanomaterials, cells
• Instrumentation, optics, engineering
• Micro/nano-fabrication and lithography
• Surface science and chemistry
• DNA, RNA, lipid nanoparticles, cells
• Biophysical assay and protocol development
• Electronics, mechanical engineering, machining

The successful candidate will have a PhD and a demonstrated track record in research with first authored peer-review publications. The position will be filled by a well-organized, enthusiastic team player with strong communication skills, who enjoys hands-on lab work and creative trouble-shooting, and who is excited to try new things. Applicants should have a strong interest in building a career in biotechnology and/or nanotechnology research and development, pioneering new biophysical techniques, and commercializing cutting edge science and technology.

Application process
Interested applicants should submit a letter of application that highlights their experience, detailed curriculum vitae including a list of publications, and contact details for 3 references. Application materials should be combined into a single PDF document and sent to leslielab@msl.ubc.ca. Please include “PDF in single-molecule biophysics and biotechnology” in the e-mail subject line. Incorrectly addressed applications will not be considered. Review of applications will begin immediately and continue until the position is filled. We will contact you only if invited for an interview.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

The UBC Michael Smith Laboratories and the Department of Biochemistry & Molecular Biology at the University of British Columbia in Vancouver invites applications for a Research Associate (RA) position in proteomics to join the laboratories of Drs. Thibault Mayor and Leonard Foster. The successful candidate will work with our mass spectrometry core facility to develop and apply new protein mass spectrometry methodology to be integrated in the research programs of the two affiliated labs. The research programs focus on protein homeostasis, host-pathogen interaction, and systems biology. Methods to develop could include, but is not limited to, probing protein-protein interactions using proximity labeling and protein correlation profiling, single-cell proteomics, structural proteomics using cross linking and limited proteolysis, quantitative approaches using SILAC and DIA, and the analysis of post translation modifications and immunopeptidomes. The RA will join a small and dynamic team at the UBC Proteomics Core Facility in Michael Smith Laboratories and will be affiliated to both multidisciplinary research teams.

The successful candidate will have a completed a PhD and have a minimum of 3 years of additional experience as Postdoctoral Researcher in academia or Scientist in the private sector. The candidate needs to have a solid track record in research with first authored peer-review research articles. The candidate will have a hands-on experience with protein mass spectrometry using LC-MS/MS approaches and a strong expertise in biochemistry, computational biology, analytical chemistry and/or biophysics. Ideally the applicant should have experience handling all aspects of the workflow associated to a proteomic experiment including sample preparation and fractionation, the loading of the samples on the instrument and analyzing the data. The applicant should be familiar with current mass spectrometry instrumentation, their maintenance, and proteomics software. The position will be filled by a well-organized, enthusiastic team player with excellent communication skills, who enjoys lab work, creative trouble-shooting, is independent and who isn’t afraid of trying new things.

Responsibilities will include:

• Develop a proteomic-based research program integrated to both affiliated labs;
• Implement or develop novel proteomics methods for sample preparation, data collection and analysis in collaboration with other researchers;
• Work independently, and collaboratively with other researchers and technicians to perform a wide range of specialized and routine laboratory techniques in proteomics;
• Analyze mass spectrometry data and help optimize the computational platforms;
• Diligently document and record results of analyses and investigations;
• Communicate recent experimental results to the Proteomics Core Facility team and with both research labs;
• Contribute to the establishment of new automation sample preparation methods, installation of a new mass spectrometry instrument and associated data analysis pipeline, and optimize the performance of existing methods and instrument;
• Help operate and maintain basic laboratory instrumentation, liquid handler, HPLC and LC-MS/MS instruments;
• Read and keep up with scientific literature relevant to proteomics research;
• Train and/or supervise scientists in the affiliated labs on the proteomics platform;
• Write and/or participate to the writing of scientific articles and research grants;

The Research Associate will need to have excellent communications and presentation skills, be highly organized, have the ability to manage time effectively, and capable to multitask by working on multiple projects over a period of time. They will be required to have exceptional attention to details, strong documentation skills and able to meet deadlines, as well as be able to work well in an academic setting, with ability to work independently and collaboratively.

Interested candidates should submit a letter of application that highlights their experience in proteomics, detailed curriculum vitae including a list of publications, and contact details for 3 references. Application materials should be combined into a single PDF document and sent to both Drs. Thibault Mayor (mayor@msl.ubc.ca) and Leonard Foster (foster@msl.ubc.ca). Please include “RA in proteomics” in the e-mail subject line, incorrectly addressed applications will not be considered. Review of applications will begin immediately and continue until the position is filled. We will contact you only if invited for an interview.

The deadline for this application is December 10, 2021 but late applications will be considered until the position is filled. The proposed start date for this position is February 1st, 2022. The appointment will initially be for one-year and is extendable depending on funding availability. The salary will start at $60,205 in accordance with the minimum standard for this employment group, and will commensurate with experience.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

The UBC Michael Smith Laboratories and the Department of Biochemistry & Molecular Biology at the University of British Columbia in Vancouver invites applications for a Postdoctoral Fellow (PDF) in proteomics to join the laboratories of Drs. Thibault Mayor and Leonard Foster. The successful candidate’s project will be to develop and apply new protein mass spectrometry methodology to be integrated in the research programs of the two affiliated labs. The research programs focus on protein homeostasis, host-pathogen interaction, and systems biology. Methods to develop could include, but is not limited to, probing protein-protein interactions using proximity labeling and protein correlation profiling, single-cell proteomics, structural proteomics using cross linking and limited proteolysis, quantitative approaches using SILAC and DIA, and the analysis of post translation modifications and immunopeptidomes. The PDF will join a small and dynamic team at the UBC Proteomics Core Facility in Michael Smith Laboratories and will be affiliated to both multidisciplinary research teams.

The successful candidate will have a completed a PhD and a demonstrated track record in research with first authored peer-review research articles. The candidate will have a hands-on experience with protein mass spectrometry using LC-MS/MS approaches and a strong expertise in biochemistry, computational biology, analytical chemistry and/or biophysics. Ideally the applicant should have experience handling all aspects of the workflow associated to a proteomic experiment including sample preparation and fractionation, the loading of the samples on the instrument and analyzing the data. The applicant should be familiar with current mass spectrometry instrumentation, their maintenance, and proteomics software. The position will be filled by a well-organized, enthusiastic team player with excellent communication skills, who enjoys lab work, creative trouble-shooting, is independent and who isn’t afraid of trying new things.

Project responsibilities will include:

• Develop a proteomic-based research program integrated to both affiliated labs;
• Implement or develop novel proteomics methods for sample preparation, data collection and analysis in collaboration with other researchers;
• Work independently, and collaboratively with other researchers and technicians to perform a wide range of specialized and routine laboratory techniques in proteomics;
• Analyze mass spectrometry data and help optimize the computational platforms;
• Diligently document and record results of analyses and investigations;
• Communicate recent experimental results to the Proteomics Core Facility team and with both research labs;
• Contribute to the establishment of new automation sample preparation methods, installation of a new mass spectrometry instrument and associated data analysis pipeline, and optimize the performance of existing methods and instrument;
• Read and keep up with scientific literature relevant to proteomics research;
• Train and/or supervise scientists in the affiliated labs on the proteomics platform;
• Write and/or participate to the writing of scientific articles and research grants;

The PDF will need to have excellent communications and presentation skills, be highly organized, manage time effectively and capable to multitask by working on multiple projects over a period of time. They will be required to have exceptional attention to details, strong documentation skills and able to meet deadlines, as well as be able to work well in an academic setting, with ability to work independently and collaboratively.

Interested applicants should submit a letter of application that highlights their experience in proteomics, detailed curriculum vitae including a list of publications, and contact details for 3 references. Application materials should be combined into a single PDF document and sent to both Drs. Thibault Mayor (mayor@msl.ubc.ca) and Leonard Foster (foster@msl.ubc.ca). Please include “PDF in proteomics” in the e-mail subject line, incorrectly addressed applications will not be considered. Review of applications will begin immediately and continue until the position is filled. We will contact you only if invited for an interview.

This posting will remain open until the position is filled. The proposed start date for this position is January 1st, 2022 and is negotiable. The appointment will initially be for one-year and is extendable depending on funding availability. Applicants are encouraged to apply for competitive fellowship awards. Salary will be commensurate with qualifications, experience and awards secured.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

The Tokuriki Lab at the Michael Smith Laboratories, University of British Columbia (https://tokurikilab.msl.ubc.ca/) is looking for postdoctoral researchers and graduate students for evolutionary biochemistry and experimental evolution.

Research projects will study the evolution of antibiotic resistance (genes and/or organisms), e.g., beta-lactamases, polymyxin resistance genes. The projects will involve in large-scale bioinformatics (sequence similarity networks, phylogenetic tree analysis and ancestral sequence reconstruction), high-throughput antibiotic resistance gene phenotyping (deep mutational scanning using illumine deep sequencing) and directed experimental evolution. But we can get excited about other questions and targets in evolutionary biochemistry!

Postdoctoral fellow candidates must possess a doctoral degree in biochemistry, microbiology, bioengineering or a related discipline. Compensation is commensurate with experience and aligned with UBC postdoctoral salaries . The ideal candidate will either have wet-lab experience or computational expertise in particular in the generation and analysis of large protein libraries (deep mutational scanning, directed evolution).

Interested candidates should reach out to Dr. Tokuriki directly with CV and one page research interest: (tokuriki@msl.ubc.ca). 

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

PhD Candidate or Postdoctoral Fellow Position – Protein phase separation and Microbiology

A PhD or PDF position is available in the Life Sciences Institute/ Michael Smith Laboratories at the University of British Columbia. The successful candidate will conduct interdisciplinary research in the areas of protein phase separation and microbiology in the laboratories of Drs. Jörg Gsponer and Yossef Av-Gay. S/he will investigate in vivo phase behaviour of a virulence factor of Mycobacterium tuberculosis. The project builds on this recent publication: https://www.pnas.org/content/116/33/16326.long.  

A successful candidate would have demonstrable (via publications, preferably) experience with biochemical, cell biology and imaging techniques. Good oral and written communication skills and the ability to work on a team project are essential.

Applicants should send their:

• curriculum vitae,
• a 1-page statement of research interests,
• and the names of at least two referees

Send application to:

Dr. Jörg Gsponer

University of British Columbia,
Michael Smith Laboratories,
2125 East Mall

Vancouver, BC, Canada  V6T 1Z4

Email:  gsponer@msl.ubc.ca