Current Positions

Postdoctoral Position in Proteostasis 

The laboratory of Thibault Mayor in the Department of Biochemistry and Molecular Biology at the University of British Columbia in Vancouver is looking for one  motivated candidate for a postdoc position.

The major focus of this research team is to elucidate how misfolded proteins are targeted for degradation by the ubiquitin proteasome system and how proteostasis is maintained in the cell. In particular, the lab is currently trying to investigate pathways that target for degradation proteins misfolded due to mutation linked to genetic diseases.

This new project will be in collaboration with the laboratory of Mikko Taipale at the University of Toronto. The Mayor lab is funded by both the CIHR and NSERC and is integrated in the Michael Smith Laboratories, a well- equipped research facility providing stimulating grounds for scientific progress in an international, multidisciplinary research environment.

Candidates are expected to be a motivated team player who fits into a multidisciplinary research environment. Candidates should have recently or nearly completed their PhD, published at least one first author research publication in a peer-reviewed journal, and have a research experience in cell biology (microscopy, flow cytometry,  CRISPR and/or RNAi), biochemistry (co-immunoprecipitation, protein purification), molecular biology. Background knowledge in the ubiquitin proteasome system or protein folding will be preferred.

Please submit your application to Thibault Mayor (mayor@mail.ubc.ca) with a curriculum vitae (including scientific publications, posters and talks) and brief research statement interest for future work with a short summary of PhD work. The position is available from Fall 2018. Applications will be reviewed after August 24, 2018 and the position will remain open until filled.

Please also visit: www.postdocs.ubc.ca/ and http://mayorlab.msl.ubc.ca

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Research Associate Position in Genetic Analysis of Cryptococcus NeoformansA Research Associate position is available in the Michael Smith Laboratories at UBC. A Ph.D. in Microbiology or a related field is required along with at least four years of postdoctoral experience. A record of publication and experience in host-pathogen interactions is also required. Knowledge and experience in the genetic manipulation, transformation, insertional mutagenesis, and phenotypic analysis of Cryptococcus neoformans and Candida albicans are essential. Applications should include a cover letter, a Curriculum Vitae and the contact information for three referees by email to kronstad@msl.ubc.ca. Please include “Genetic Analysis of Cryptococcus Neoformans Search” in the email subject line; incorrectly addressed applications will not be considered. The salary will be commensurate with qualifications and experience. The deadline for applications is January 4, 2019 and the expected start date is February 27, 2019.

Materials should be sent by email to:
Dr. J.W. Kronstad
Michael Smith Laboratories
University of British Columbia
kronstad@msl.ubc.ca

“Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.”

“All qualified candidates are encouraged to apply; however Canadian and permanent residents of Canada will be given priority.”

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Research Associate Position in Neuroinflammation

For more information: https://www.hr.ubc.ca/jobs/staff.php?job_id=31013

Training & expectations: Major areas of focus will include inflammatory mediators, oxidative stress, environmental stressors, immune populations, neurodegeneration and repair. The successful candidate will have a solid understanding and demonstrated proficiency in several of the following and others will be provided on the job:

• Cell culture and aseptic technique, preferably involving both isolation and maintenance of rodent primary cultures as well as cell lines.
• Aseptic technique and experience with human blood handling for the isolation of PBMC and subsequent culture/assay
• Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques, including many of the following:
  RNA/DNA isolation, quantitative PCR, transfection, siRNA knockdown and cDNA construct knockin, flow cytometry, immunohisto- and cytochemistry on cells as well as frozen and formalin-fixed, paraffin embedded tissues, fluorescence and light microscopy – conventional and/or confocal; ELISA, protein isolation and western blotting;
• Willingness to work with small rodents is essential. Able to carry out and oversee procedures involving small rodents including immunization/injections, necropsy, blood sampling, and minor surgical procedures involved in animal surgery; applicants with experience in pre-clinical models of neurodegenerative diseases including MS are especially encouraged to apply.
• Maintenance/monitoring of colonies of transgenic animals, including colony breeding, screening and management.
• Excellent verbal and written communication
• Understanding of experimental design and assay optimization is important along with ability to work well with others and to work independently,

Interested applicants are invited to review our website for more information, www.quandtlab.com.

“Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.”

“All qualified candidates are encouraged to apply; however Canadian and permanent residents of Canada will be given priority.”

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Research Associate Position in Proteostasis

The laboratory of Dr. Thibault Mayor at The University of British Columbia in Vancouver is looking for a motivated Research Associate to fill a position starting in the fall of 2018. The anticipated start date is November 15, 2018. The primary focus of this research team is to elucidate how misfolded proteins are targeted for degradation by the ubiquitin proteasome system and how proteostasis is maintained in the cell. The Mayor lab is funded by both the CIHR and NSERC and is part of the Michael Smith Laboratories and the Department of Biochemistry & Molecular Biology. The lab is located in a well-equipped research facility that provides a stimulating international and multidisciplinary research environment.

The candidate is expected to be a motivated team player, should have completed their PhD and have at least three years of postdoctoral research experience in a field related to protein homeostasis (e.g., the ubiquitin proteasome system or protein folding). The candidate needs to have a strong expertise in cell biology including extensive experience in mammalian tissue culture cell techniques, be well versed in most standard molecular biology methods, have strong skills in biochemistry including protein expression and purification, and proficiency in one high throughput approach such as mass spectrometry or RNA-Seq analysis. Considered applicants will have published several first author research manuscripts in peer-reviewed journals from both their PhD and postdoctoral work. Applicants also need to demonstrate experience in writing research grant proposals, for instance evidenced by obtaining a postdoctoral fellowship or other.

Send applications by email to Dr. Thibault Mayor (mayor@mail.ubc.ca) with a Curriculum Vitae and a Letter of Motivation. Please include “Research Associate Position in Proteostasis” in the email subject line; incorrectly addressed applications will not be considered. Please indicate your legal status to work in Canada.

The salary will be commensurate with qualifications and experience. The position is available starting fall 2018. Applications will be reviewed after October 26, 2018 and the position will remain open until filled.

“Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.”

“All qualified candidates are encouraged to apply; however Canadians and permanent residents of Canada will be given priority.”

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