Departments
- Department of Biochemistry and Molecular Biology
- Michael Smith Laboratories
- Genome Sciences and Technology (GSAT) Graduate Program
- Bioinformatics Graduate Program
Professional Profile
- University of Lausanne, 1997, MD
- University of Zurich, 2002, PhD (Biochemistry)
- University of Cambridge, 2003, Post-doctoral fellow
- Laboratory of Molecular Biology in Cambridge, 2006, MRC Research fellow
Research Area
Advances in high-throughput biology and the associated assembly of pan-omic data provide tremendous opportunities for the systems-level investigation of biological processes. Our lab is interested in the development and application of computational tools that, guided by fundamental principles of biochemistry and biophysics, exploit genomic, transcriptomic and proteomic data in order to get new insights into cellular processes such as signaling and quality control, and how these vital processes are affected in cancer and neurodegenerative disorders, respectively.
Research Questions
- How do intrinsically disordered regions contribute to allosteric protein regulation
- How does protein phase separation enhance cellular signaling?
- How is intracellular protein aggregation controlled?
- Which genetic factors modulate the phenotype of all proteinopathies?
Research Keywords
Biochemistry, bioinformatics, biophysics, systems biology, biomolecular engineering, drug discovery, personalized medicine, protein regulation, proteomics, computational modeling, macromolecular biochemistry, neurology, protein design
To learn more about the Gsponer Lab, please visit gsponerlab.msl.ubc.ca.