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BC Cancer Research Seminar Series: Dr. Colin Sheppard
September 9, 2019 @ 12:00 pm - 1:00 pm
BC Cancer Research Seminar Series presents a seminar:
Dr. Colin Sheppard
Honorary Professional Fellow, University of Wollongong, Australia
External Collaborator and Visiting Scientist with the Italian Institute of Technology
Date: Monday, September 9, 2019
Time: 12:00pm to 1:00pm
Location: Gordon & Leslie Diamond Family Theatre, BC Cancer Research Centre, 675 W.10th Ave.
Videolinked to: FVC – room 2035, VIC – room #3, CSI – Shuswap room, CN – Salmon room, UBC Biomedical Research Centre – room 351, Michael Smith Labs – room 303, C&W – room K4-142
Title: Confocal microscopy: past, present and future
Abstract:
Memory CD8 T cells arise following infection from a heterogenous population of effector T cells that contains cells of various differentiation states. Many of these effector CD8 T cells develop into end-stage terminal effector cells that die following infection and a smaller portion develops into cells with greater memory cell potential and longevity. Understanding how effector CD8 T cell differentiation is regulated to generate cells of diverse cell fates is important and much progress has been made in identifying several transcriptional factors that regulate effector and memory cell fates, function and phenotypes. In this talk we will discuss how the epigenetic landscape of different subsets of effector T cells varies and impacts their long-term fates and multipotency.
Bio:
Colin Sheppard is an Honorary Professorial Fellow at the University of Wollongong, Australia, and also an External Collaborator and Visiting Scientist with the Italian Institute of Technology, Genoa, Italy. Previously he was Professor and Head in the Department of Bioengineering at the National University of Singapore; Professor of Physics at the University of Sydney; and University Lecturer in Engineering Science at the University of Oxford. He obtained his PhD from the University of Cambridge. He has held visiting positions at many different institutions, including UC-Berkeley, MIT, EPFL, TU-Delft and Tokyo University. He developed an early laser microscope (1975), patented scanning microscopy using Bessel beams (1977), published the first demonstration of scanning two-photon microscopy (SHG) (1977), proposed two-photon fluorescence and CARS microscopy (1978), launched the first commercial confocal microscope (1982), and developed the first confocal microscope with computer control and storage (1983). In 1988, he proposed scanning microscopy using a detector array with pixel reassignment, now known as image scanning microscopy.
Confocal microscopy has made a dramatic impact on biomedical imaging, in particular, but also in other areas such as industrial inspection. Confocal microscopy can image in 3D, with good resolution, into living biological cells and tissue. I have had the good fortune to be involved with the development of confocal microscopy over the last 40 years. Other techniques have been introduced that overcome some of its limitations, but still it is the preferred choice in many cases. And new developments in confocal microscopy, such as focal modulation microscopy, and image-scanning microscopy, can improve its performance in terms of penetration depth, resolution and signal level.
Sponsored by: BC Cancer Foundation
Hosted by: Dr. Haishan Zeng
