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Stewart Blusson Quantum Matter Institute: Vahid Sandoghdar
February 19, 2019 @ 2:00 pm - 3:00 pm
Single protein imaging talk by Vahid Sandoghdar,
Director at the Max Plank Institute for Science of Light in Erlangen, Germany.
Date and time: Tuesday, February 19 at 2pm
Location: BRIM 311
The Sandoghdar Division of Nano-Optics, https://www.mpl.mpg.de/divisions/sandoghdar-division/, combines concepts from quantum optics, laser spectroscopy, cryogenics, optical imaging, scanning probe technology and nanofluidics to address a wide spectrum of scientific questions, ranging from quantum optics to biophysics. Please come to meet Dr. Sandoghdar, and to hear about his biophysics-related work on imaging single proteins next Tuesday afternoon.
Abstract:
Proteins are some of the most ubiquitous and important components of a biological cell. Both the structure and the dynamics of proteins play a decisive role in their function over time scales ranging from sub-nanoseconds to minutes and hours. Thus, it would be extremely insightful if one could investigate single proteins with very high spatial resolution over many temporal decades. Here, we report on two very different efforts in our laboratories, which open doors to very new studies. First, we apply interferometric scattering (iSCAT) microscopy on proteins with unprecedented combination of spatial and temporal resolution. We discuss our recent results from several projects on the diffusion of lipids in model membranes as well as diffusion and transport of membrane proteins as well as real-time secretion of proteins from a live cell. In a second approach, we exploit cryogenic fluorescence experiments to perform localization microscopy at the sub-nanometer level.
