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Harry Brumer

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Harry Brumer

Professor

Harry Brumer's picture

Office Phone Number

604-827-3738

Lab Phone Number

604-827-3759

Email Addresses

brumer@msl.ubc.ca

UBC Mailing Address

Harry Brumer, Ph.D., Professor
Michael Smith Laboratories
University of British Columbia
2185 East Mall, Room 325
Vancouver, BC, V6T 1Z4
Canada

Building

MSL

Room Number

325

Name

Brumer Lab

Building

MSL

Room Number

263

Professional Profile

Apr. 2015 - present: Associate Member, Department of Biochemistry and Molecular Biology, University of British Columbia
Jul. 2014 - present: Associate Member, Department of Botany, University of British Columbia
Sep. 2011 - present: Professor, Michael Smith Laboratories and Department of Chemistry, University of British Columbia
2011 - 2012: Professor, School of Biotechnology, Royal Institute of Technology (KTH), Stockholm, Sweden
2004 - 2011: Associate Professor (Docent), School of Biotechnology, KTH
1999 - 2004: Assistant Professor (Forskarassistent), School of Biotechnology, KTH
1998 - 1999: Post-doctoral researcher, Department of Chemistry, University of British Columbia, Vancouver, Canada (S.G. Withers)
1996 - 1998: Ph.D., University of Manchester Institute of Science and Technology (UMIST), Manchester, UK (M.L. Sinnott)
1993 - 1995: M.Sc., University of Illinois at Chicago (UIC), IL, U.S.A. (R.M. Moriarty)
1989 - 1993: B.Sc. Biochemistry, Michigan State University, E. Lansing, MI, U.S.A. (cum laude)

See also:
All publications | Current Team Members & Alumni

Research Area

Fundamental and applied carbohydrate enzymology

The focus of our Carbohydrate Enzymology Research Group is to understand the way in which particular enzymes act to alter the structure of polysaccharides found in biomass (especially plant cell walls and wood fibers), and to harness these enzymes for applications. We are primarily interested in the carbohydrate-active enzymes (CAZymes) which synthesize, re-arrange, and degrade glycosidic bonds. Studies of carbohydrate oxidases involved in polysaccharide functionalisation comprise another primary research area.

In the biological context, we aim to elucidate the molecular details of polysaccharide synthesis and deconstruction in:

  • biogenesis of plant cell walls
  • recycling of biomass in the global carbon cycle
  • breakdown of dietary fibre (non-starch polysaccharides) by the human gut microbiota
    [An excellent popular science overview of our research in this area, including an animated video and an audio interview with Prof. Brumer, has been produced by UBC SCIE300 students - click here to check it out.]

The discovery and characterisation of new enzymes involved in these processes provides a foundation for the development of enzyme technology for the improved use of renewable biomass resources in the forest products, agricultural, and textile industries.

Outreach

We routinely work with teachers and students to convey the importance of the research we do to non-specialists. Some examples include:

  • A blog post and video on the digestion of dietary fiber by human gut bacteria, produced by UBC SCIE300 students.
  • A WebQuest on the relationship of dietary complex carbohydrates and health, produced by local teacher Michelle Johnsrude of Highroad Academy.
  • A WebQuest on the our relationship with bacteria in our environment, produced by local teacher Albert Chang of David Thompson Secondary School.

Research tools and methods

We employ a wide variety of techniques to learn more about enzymes relevant to biomass utilization and fiber modification:

Organic chemistry and chemical biology
Synthesis of modified substrates as probes of enzyme mechanism or to introduce specific chemical functionality into carbohydrate polymers.
Representative publications: Pub. 1| Pub. 2| Pub. 3| Pub. 4
Molecular phylogeny, molecular biology, and heterologous protein expression
Identification, cloning, and recombinant expression of genes encoding enzyme targets with unique biological/biochemical function and/or application potential.
Representative publications: Pub. 1| Pub. 2| Pub. 3| Pub. 4
Protein biochemistry
Purification and basic biochemical characterization of native and heterologously expressed enzymes.
Representative publications: Pub. 1| Pub. 2
Mechanistic enzymology
Thorough examination of enzyme mechanisms using specifically designed substrates and detailed kinetic analyses.
Representative publications: Pub. 1| Pub. 2| Pub. 3| Pub. 4
Enzyme engineering
Rational modification of enzymes for various applications using knowledge of protein structure and enzyme mechanism.
Representative publications: Pub. 1| Pub. 2| Pub. 3
Protein/enzyme structure-function analysis
Via collaboration with world-leading protein crystallographers, we use the above tools to develop a better understanding of how protein structure dictates enzyme catalytic properties.
Representative publications: Pub. 1| Pub. 2| Pub. 3| Pub. 4
Carbohydrate-based materials development
Synthetic chemistry and enzyme technology are combined to develop chemo-enzymatic technologies to expand the performance of polysaccharides and cellulosic fibers.
Representative publications: Pub. 1| Pub. 2| Pub. 3| Pub. 4| Pub. 5| Pub. 6
For a complete publication list, please see this page. Interested in graduate studies? Please see this information page at UBC Chemistry. As an Associate Member, Prof. Brumer also routinely co-supervises graduate students in the Department of Botany.