- Michael Smith Laboratories
- Department of Biochemistry and Molecular Biology, Assistant Professor
- Centre for Blood Research, Member
- School of Biomedical Engineering, Associate Member
- Genome Sciences and Technology (GSAT) Graduate Program
- Ph.D., University of Chicago Postdoctoral fellow, Massachusetts Institute of Technology
Understanding the dynamics of biochemical networks is important for understanding life at the systems level and has practical implications for Medicine, Engineering, Biology, and Chemistry. The complex network of hemostasis consists of over 100 coupled reactions and has the death-defying function of regulating blood coagulation. Research in my laboratory focuses on three problems related to blood coagulation:
- Understanding the biophysical mechanisms by which blood clots form and degrade
- Controlling these processes to eliminate unwanted coagulation
- Using coagulation as a scaffold for delivering therapeutics to diseased vasculature
This research lies at the interface of Chemical Biology, Bioengineering and Medicine. The techniques we use include microfluidics, reconstituted protein systems, biomaterial synthesis, numerical simulations, and disease models of coagulation and atherosclerosis.
Lab Research Questions
- Does soil and dirt help prevent hemorrhage and heal wounds?
- Can platelets be engineered to enhance blood transfusions?
- Can silencing the mRNA of coagulation factors prevent heart attack and stroke?
Biochemistry, biotechnology, biological imaging, translation, biophysics, bioengineering, biomolecular engineering, enzymology, protein regulation, gene/cell therapy systems, cell delivery, microfluidics, biomaterials and biomechanics, drug delivery
To learn more about the Kastrup Lab, please visit kastruplab.msl.ubc.ca.