- Michael Smith Laboratories
- Department of Biochemistry and Molecular Biology
- School of Biomedical Engineering
- Centre for Blood Research
- Genome Sciences and Technology (GSAT) Graduate Program
- Ph.D., University of Chicago Postdoctoral fellow, Massachusetts Institute of Technology
Understanding the dynamics of biochemical networks is important for understanding life at the systems level and has practical implications for Medicine, Engineering, Biology, and Chemistry. The complex network of hemostasis consists of over 100 coupled reactions and has the death-defying function of regulating blood coagulation. Research in my laboratory focuses on three problems related to blood coagulation:
- Understanding the biophysical mechanisms by which blood clots form and degrade
- Controlling these processes to eliminate unwanted coagulation
- Using coagulation as a scaffold for delivering therapeutics to diseased vasculature
This research lies at the interface of Chemical Biology, Bioengineering and Medicine. The techniques we use include microfluidics, reconstituted protein systems, biomaterial synthesis, numerical simulations, and disease models of coagulation and atherosclerosis.
Lab Research Questions
- What new technologies are needed to halt bleeding in the most severe cases of hemorrhage?
- Can platelets be genetically engineered to be more effective in blood transfusion?
- Do soil and microbes in wounds influence bleeding?
Biochemistry, biotechnology, biological imaging, translation, biophysics, bioengineering, biomolecular engineering, enzymology, protein regulation, gene/cell therapy systems, cell delivery, microfluidics, biomaterials and biomechanics, drug delivery
To learn more about the Kastrup Lab, please visit kastruplab.msl.ubc.ca.